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5 edition of Genomics in Cancer Drug Discovery and Development, Volume 96 (Advances in Cancer Research) found in the catalog.

Genomics in Cancer Drug Discovery and Development, Volume 96 (Advances in Cancer Research)

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Published by Academic Press .
Written in English


Edition Notes

ContributionsGarret Hampton (Editor), Karol Sikora (Editor), George F. Vande Woude (Series Editor), George Klein (Series Editor)
The Physical Object
Number of Pages432
ID Numbers
Open LibraryOL7324945M
ISBN 100120066963
ISBN 109780120066964


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Genomics in Cancer Drug Discovery and Development, Volume 96 (Advances in Cancer Research) Download PDF EPUB FB2

Genomics in Cancer Drug Discovery and Development. George F. Vande Woude and George Klein. Vol Pages () Download full volume. Previous volume. Next volume. Actions for selected chapters select article Biomarker Assay Translation from Discovery to Clinical Studies in Cancer Drug Development: Quantification of Emerging.

Get this from a library. Genomics in cancer drug discovery and development. [Garret M Hampton; Karol Sikora;] -- The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research.

This volume stands as the first ever thematic volume in the series. Next-generation sequencing (NGS) enables researchers to better understand the biology that drives cancer predisposition and proliferation. These insights can support the development of targeted therapeutics and multi-analyte tumor analysis.

NGS also opens the door for discovery of novel methods to monitor cancer treatment and recurrence. Contributors to Volume 96 --Introduction / Garret M. Hampton, Karol Sikora --Biomarker Discovery in Epithelial Ovarian Cancer by Genomic Approaches / Samuel C.

Mok, Kevin M. Elias, Kwong-Kwok Wong, Kae Ho, Tomas Bonome, and Michael J. Birrer --Mass Spectrometry: Uncovering the Cancer Proteome for Diagnostics / Da-Elene van der Merwe, Katerina.

Genomics, particularly high-throughput sequencing and characterization of expressed human genes, has created new opportunities for drug discovery. Knowledge of all the human genes and their functions may allow effective preventive measures, and change drug research strategy and drug discovery development processes.

Pharmacogenomics is the Cited by: The editors have strived to make every chapter in this book present the composite of relevant science and of clinical knowledge about each cancer.

The evolution of disease Volume 96 book the patient is critical to appreciating the special molecular characteristics of that particular type of cancer by: Patel AC () Clinical relevance of target identity and biology: implications for drug discovery and development.

J Biomol Screen – CrossRef PubMed Google Scholar Pelz O, Gilsdorf M, Boutros M () Web cellHTS2: a web-application for the analysis of high-throughput screening by: 3.

More buying choices £ (13 used & Genomics in Cancer Drug Discovery and Development offers) Genomics in Cancer Drug Discovery and Development (Advances in Cancer Research): Volume 96 by Garret Hampton.

Genomics, particularly high‐throughput sequencing and characterization of expressed human genes, has created new opportunities for drug discovery. Knowledge of all the human genes and their functions may allow effective preventive measures, and change drug research strategy and drug discovery development by: Genomics, the systematic study of all of an organism's genes, represents a highly efficient way to discover new drugs that are relatively easily brought to market.

As such, it is clear that genomics will play a crucial role in the development of drugs to treat a wide range of conditions. Abnormalities in genes or gene activity underlie most Cited by: 5.

Exploring innovative routes of drug discovery in the postgenomic era, Microbial Genomics and Drug Discovery examines bioinformatic and genomic approaches for the identification, detection, selection, and validation of new antibacterial targets and vaccine candidates.

The book discusses potential pat. The Genomics of Drug Sensitivity in Cancer (GDSC) database () is designed to facilitate an increased understanding of the molecular features that influence drug response in cancer cells and which will enable the design of improved cancer therapies.

GDSC holds and annotates large datasets on drug sensitivity in cancer cells Cited by: genomics and bioinformatics in drug discovery” in the PSB is to cover recent advances in developing and applying computational approaches to enable drug discovery in the above-described areas.

Furthermore, the session is also intended to promote more interactions and collaborations between academic and industry experts.

Pilot experiments, including the NCI’s Cancer Target Discovery and Development (CTD²) Network Opens in a New Tab, prove that correlations of cancer genetic features and drug efficacy can be established that parallel the dramatic consequences seen with the small number of cancer patients currently taking genetically matched drugs.

Cancer Drug Design and Discovery: Edition 2 - Ebook written by Stephen Neidle. Read this book using Google Play Books app on your PC, android, iOS devices.

Download for offline reading, highlight, bookmark or take notes while you read Cancer Drug Design and Discovery: Edition : Stephen Neidle. The Impact of Genomics on Drug Discovery. that have been successfully deployed to a diverse collection of issues during drug discovery and development.

Techniques such as high-throughput off. Genomics & Proteomics Based Drug Discovery 1. Genomics & Proteomics Based Drug DISCOVERY Dr.

Basavaraj K. NanjwadePh. D Associate Professor Department of Pharmaceutics KLE University BELGAUM – 2. Drug Discovery & Development Plants & Animals Genetics and Genomics development of new statistical methods to understand the interplay of genetic and environmental factors that cause lung cancer development.

He wrote a book 'Forward-Time Population Genetics Simulations: Methods, Implementation, and Applications') with coauthors Dr. lllumina brings innovation to cancer drug development by offering comprehensive genomic solutions working in collaboration with leading pharmaceutical providers.

NGS and Companion Diagnostics Some NGS discoveries have become the basis for companion diagnostics and laboratory developed tests (LDT) now in use in molecular diagnostic laboratories. Abstract: New biotechnology and drug discovery technologies are facilitating the rapid expansion of the clinical drug chest, empow-ering clinicians with a better understanding of disease as well as novel modalities for treating patients.

Important research tools and themes include genomics, proteomics, ligand-receptor interaction,Cited by: Documenting the latest advances, this book is of interest to physicians and clinical fellows in the front line of the war on cancer, as well as to basic scientists working in the fields of cancer biology, drug development, biomarker discovery, and biomedical engineering.

Introduction to the Drug Discovery Process. The process of drug discovery within the modern scientific context is quite complex, integrating many disciplines, including structural biology, metabolomics, proteomics, and computer science, just to name a process is generally quite tedious and expensive, given the sheer amount of possibilities of drug-to-target interactions in-vivo, and.

This book covers almost all fields of cancer genetics and genomics for personalized medicine. Targeted therapy, or precision medicine, or personalized medicine is becoming a standard treatment for many diseases, including cancer. However, how much do we know about the personalized medicine approach.

Title:Advances in Drug Discovery: Impact of Genomics and Role of Analytical Instrumentation VOLUME: 13 ISSUE: 4 Author(s):Ambavaram V.B.

Reddy, Zulkifli Yusop, Jafariah Jaafar, Vemula Madhavi and Gajulapalle Madhavi Affiliation:Department of Chemistry, Universiti Teknologi Malaysia, JohorMalaysia.

Keywords:Bioinformatics, 3-D printing, drug discovery, analytical techniques, genome Author: Ambavaram V.B. Reddy, Zulkifli Yusop, Jafariah Jaafar, Vemula Madhavi, Gajulapalle Madhavi.

Genome-Based Therapeutics: Targeted Drug Discovery and Development: The National Academies Press. doi: / The first example was the use of crizotinib for non-small-cell lung cancer, the second was the use of pomaglumetad methionil for schizophrenia, and the third was the use of ivacaftor for cystic fibrosis.

Take Africa for example where a drug used to treat HIV caused horrible side-effects for those with certain genetics in Zimbabwe.

In 6 the country issued a single-pill therapy for HIV called efavirenz. The drug was cheaper and easier than the previous three-drug cocktail used but it brought about a new set of : Reece Armstrong.

The application of genomics in cancer medicine will no doubt prove to be beneficial in the long run. The evolution of genomics and its integration in this field is a complex and challenging process.

However, progress is being made and instead of treating cancer, cancer could be eliminated before its appearance by modifying the gene responsible. Jumping into Genomics for Drug Discovery Drug companies are building up genomic databases to aid in the quest for new therapeutics, Reuters reports.

Genomics of Drug Sensitivity in Cancer (GDSC): a Resource for Therapeutic Biomarker Discovery in Cancer Cells The Harvard community has made this article openly available. Please share how this access benefits you.

Your story matters Citation Yang, Wanjuan, Jorge Soares, Patricia Greninger, Elena J. These techniques were used to identify potential new therapeutics for cancer, psychiatric disease, and other complex medical conditions. Consortium Director and Scientists Scherer, Christina, 5UL1DE GENOMICS BASED DRUG DISCOVERY Golub, Todd, 1RL1CA DISCOVERY PIPELINE Schreiber, Stewart, 1RL1HG TARGET ID.

In Cancer Chemoprevention, Volume 2: Strategies for Cancer Chemoprevention, leading chemopreventives investigators comprehensively describe the exciting methodologies that are accelerating progress in the chemoprevention field and review the state of clinical development of preventive agents in the major human cancer target : Humana Press.

Genomics has created new ways of examining genes, which open new strategies for drug development and control of human diseases. Results In silico analyses and manual mining selected initially 57 potential drug targets, based on 55 genes experimentally confirmed as essential for Candida albicans or Aspergillus fumigatus and other 2 genes (kre2 Cited by: FIG.

Drug discovery & development market, - (USD Million) FIG. Research market, - (USD Million) FIG. Genomics in cancer caremarket share by technology, & FIG.

Genome sequencing market, - (USD Million) FIG. PCR market. Title: Translation of New Technologies: From Basic Research to Drug Discovery and Development VOLUME: 5 ISSUE: 3 Author(s):Nirmala Bhogal and Michael Balls Affiliation:FRAME, Russell&Burch House, North Sherwood Street, Nottingham NG1 4EE, UK.

Keywords:Biomarkers, culture models, in silico, nanotechnology, systems biology Abstract: Despite increasing investment in drug discovery Cited by: Stephenson’s analogy for this new approach to disease mouse model development is the difference between your old cell-phone and the latest smartphone.

Traditional mouse models are “your Nokiaand that’s a great phone: it's solid, has a battery that last a week, you can play Snake on it, you can call your friends, you can text message.

The Single-Cell Genomics Center is expected to act as a hub for collaboration among single-cell genomics researchers in many fields, including stem cells and cancer biology. Single-cell genomics holds much potential for more targeted drug discovery through a better understanding of cells and their interactions.